Gold nanosystems improve male reproductive function

Abstract

Polymers with a dextran core and grafted polyacrylamide chains dextranpolyacrylamide (D-PAA) in the anionic form of D-g-PAA(PE), as a polymer matrix carrier, in particular gold nanoparticles (AuNPs) - are being actively studied. Treatment of 9,78 mg/kg D-g-PAA(PE)/AuNPs leads to disorder of the male reproductive system, but is not critically dangerous for therapeutic use. Whereas the treatment of 1,96 mg/kg D-g-PAA(PE)/AuNPs has possible therapeutic applications to improve male reproductive function. The effect of such gold nanosystems may reduce oxidative stress and improve sperm DNA repair, which requires further study.