1. eIEU
  2. European School of Medicine
  3. Кафедра фундаментальних та медико-профілактичних дисциплін
Please use this identifier to cite or link to this item: http://e.ieu.edu.ua/handle/123456789/823
Full metadata record
DC FieldValueLanguage
dc.contributor.authorHolodaieva, Olena-
dc.contributor.authorLushchai, Maksym-
dc.date.accessioned2024-01-12T08:18:36Z-
dc.date.available2024-01-12T08:18:36Z-
dc.date.issued2023-05-06-
dc.identifier.citationHolodaieva O, Lushchai M. Study of the influence of the structure of the molecule on its ability to selectively inhibit BACE1// Scientific research in the modern world. Proceedings of the 7th International scientific and practical conference. Toronto, Canada. 2023. Pp. 161-165.uk
dc.identifier.isbn978-1-4879-3795-9-
dc.identifier.urihttp://e.ieu.edu.ua/handle/123456789/823-
dc.description.abstractComputer modeling of potential inhibitors of hBACE1 in relation to ADAM10 and γ-secretase was carried out. The influence of the basicity of the ligand molecule and the presence of a trifluoromethyl group in the aromatic ring the affinity energy and selectivity of individual members of the protease membrane complex consisting of hBACE1, ADAM10 and γ-secretase was studied. The influence of the molecular weight of the ligand on the affinity energy was studied as well. A number of potentially the most selective compounds that form stronger complexes with hBACE1, selectively inhibiting hBACE1 in the enzymatic membrane complex, compared to the original ligand, were identifieduk
dc.language.isoenuk
dc.publisherSCIENTIFIC RESEARCH IN THE MODERN WORLD Proceedings of VII International Scientific and Practical Conference Torontouk
dc.subjectdocking simulationuk
dc.subjecthuman beta-secretase 1uk
dc.subjecthBACE1uk
dc.subjectinhibitorsuk
dc.subjectβ-amyloiduk
dc.subjectAβuk
dc.subjectAlzheimer's diseaseuk
dc.subjectADuk
dc.titleSTUDY OF THE INFLUENCE OF THE STRUCTURE OF THE MOLECULE ON ITS ABILITY TO SELECTIVELY INHIBIT BACE1uk
dc.typeArticleuk
Appears in Collections:Кафедра фундаментальних та медико-профілактичних дисциплін

Files in This Item:
File Description SizeFormat 
SCIENTIFIC-RESEARCH-IN-THE-MODERN-WORLD-4-6.05.23.pdf867.53 kBAdobe PDFView/Open
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.